PTEN (gene) - Wikipedia
Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer.
About Mutations in the PTEN Gene - Memorial Sloan Kettering Cancer Center
Jul 17, 2023 — If you have a mutation in the PTEN gene, this means you have a condition called Cowden syndrome. Cowden syndrome increases your risk for certain types of cancers, including: Breast cancer. Uterine (endometrial) cancer. Thyroid cancer. Colorectal (colon and rectal) cancer and colon polyps. Kidney cancer.
PTEN Hamartoma Tumor Syndrome - Children's Hospital of Philadelphia
PHTS is caused by alterations, also known as “mutations," of the PTEN gene on chromosome 10. In some cases, all or part of the gene is deleted. The condition can be inherited or caused by “new” mutations in one of the father’s sperm, mother’s eggs, or in a cell of the developing fetus.
PTEN gene - MedlinePlus
More than 30 mutations in the PTEN gene have been found to cause Bannayan-Riley-Ruvalcaba syndrome. Common features of this condition include a large head size (macrocephaly), multiple noncancerous tumors and tumor-like growths called hamartomas, and …
PTEN Hamartoma Tumor Syndrome - Cleveland Clinic
PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome (BRRS). With PHTS, a mutation of your PTEN gene causes uncontrolled cell growth. PHTS can lead to benign tumors and skin growths, and can increase your cancer risk.
PTEN Hamartoma Tumor Syndrome - GeneReviews® - NCBI Bookshelf
Nov 29, 2001 — The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN -related Proteus syndrome (PS), and PTEN -related Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, kidney, and endometrium.
The Clinical Spectrum of PTEN Mutations - PubMed
Jan 27, 2020 — PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. PTEN dysfunction causes dysregulation of this and other pathways, resulting in overgrowth.
The functions and regulation of the PTEN tumour suppressor
Jun 1, 2018 — PTEN is one of the most frequently mutated tumour suppressor genes in human cancer. It was identified simultaneously by three groups in 1997 as a candidate tumour suppressor gene 1, 2 and...
If you have a mutation in the PTEN gene, this means you have a condition called Cowden syndrome. Cowden syndrome increases your risk for certain types of cancers, including: Breast cancer. Uterine (endometrial) cancer. Thyroid cancer. Colorectal (colon and rectal) cancer and colon polyps. Kidney cancer.
PTEN: Multiple Functions in Human Malignant Tumors
Feb 16, 2015 — PTEN Loss in Human Cancer. Germline mutations of PTEN are the underlying genetic causes of related disorders clinically referred to as PTEN hamartoma syndromes (PHTS) including: Cowden syndrome, Bannayan–Zonana syndrome, Lhermitte–Duclos syndrome, Proteus syndrome, and Proteus-like syndrome.