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Treatment and prognosis of IgG4-related disease - UpToDate
WEBMar 25, 2024 · Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs [ 1,2 ]. Common presentations include type 1 (IgG4-related) autoimmune pancreatitis (AIP); IgG4-related sclerosing cholangitis; major salivary gland enlargement or sclerosing sialadenitis; orbital disease, …
IgG4-Related Disease - The Merck Manuals
WEBIgG4-related disease (IgG4-RD) is a chronic, immune-mediated disorder that often manifests with multiorgan involvement and tumor-like masses most often affecting the pancreas, bile ducts, lacrimal glands, orbital tissues, salivary glands, lungs, kidneys, retroperitoneal tissues, aorta, meninges, and thyroid gland.
The unique properties of IgG4 and its roles in health and disease
WEBApr 24, 2023 · IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore,...
Clinical manifestations and diagnosis of IgG4-related disease
WEBMar 20, 2024 · Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that is capable of affecting multiple organs [ 1-3 ]. Organs affected by IgG4-RD share pathologic, serologic, and clinical features.
IgG4-Related Disease - StatPearls - NCBI Bookshelf
WEBAug 8, 2023 · IgG4-related disease (IgG4-RD) is known as an IgG4-related systemic disease, hyper-IgG4 disease, IgG4-related autoimmune disease, IgG4-associated disease, IgG4-related sclerosing disease, and IgG4-syndrome.
What is IgG4? A review of the biology of a unique …
WEBImmunoglobulin G. IgG4 is a unique antibody biologically and structurally. Increased understanding of its precise role in the clinical syndromes that comprise IgG4-RSD may ultimately elucidate the underlying pathogenesis.
IgG4-related disease | About the Disease | GARD - Genetic and …
WEBIgG4-related disease is an immune-mediated condition that can affect multiple organ systems. Common features include IgG4-related autoimmune pancreatitis, swelling of or within an organ system (an inflammatory pseudotumor), salivary gland disease (which can lead to enlargement of the salivary glands), swollen lymph nodes (lymphadenopathy), …
Advances in the diagnosis and management of IgG4 related disease - The BMJ
WEBJun 16, 2020 · IgG4 related disease is highly treatable and responds promptly to glucocorticoids, but it can lead to end stage organ failure and even death if unrecognized. Prolonged courses of corticosteroids are often needed to maintain remission because the disease relapses in most patients.
Diagnostic and treatment workup for IgG4-related disease - PMC
WEBIgG4 related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory condition often involving several organ systems at the time of diagnosis or over time.
IgG4-related disease: why is it so important? - PMC
WEBJun 30, 2018 · IgG4-related disease (IgG4-RD) is a newly classified, immunological condition. It involves potentially multi-organ inflammation and fibrosis, characterized (in most cases) by elevated serum IgG4 levels and presenting as tissue edema with fibrosis and marked inflammatory infiltration of IgG4-positive plasma cells.
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