eLife18h
SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote ...
eLife21h
Hippocampus and striatum show distinct contributions to longitudinal changes in value-based learning in middle childhood
Longitudinal and computational analyses reveal an early and temporally stable hippocampal and striatal involvement in reinforcement learning in 6-to-7-year-old children.
eLife22h
Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome
The capacity for new cerebellum-dependent learning is influenced by the recent history of neural activity in a mouse model of Fragile X syndrome, suggesting a role for metaplasticity.
eLife1d
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
Centrioles have a unique, conserved architecture formed by three linked “triplet” microtubules arranged in nine-fold symmetry. The mechanisms by which these triplet microtubules are formed are not ...
eLife1d
Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
College of Life Sciences, Zhejiang University; Hangzhou 310058, China School of Life Sciences, Westlake University; Hangzhou 310024, China Zhejiang Key Laboratory of Structural Biology, School of Life ...
eLife1d
Nutritional state-dependent modulation of Insulin-Producing Cells in Drosophila
Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, 97074, Germany Institute of Zoology, Department of Biology, University of Cologne, ...
eLife1d
Cell Migration: Pump up the volume
Cell migration is essential for most processes in the body, such as embryonic development, immune responses or wound repair. The ability of cells to migrate is a complex phenomenon that depends on ...
eLife1d
Author Experience: ”Smooth, fair, and transparent”
Open annotations (there are currently 0 annotations on this page). Ushio Masayuki is Assistant Professor at the Department of Ocean Science at the Hong Kong University of Science and Technology (HKUST ...
eLife1d
Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development
The developmental TGFβ pathway is essential for cell migration, cell-cell communication, adhesion, apoptosis, and matrix remodeling. Dysregulation of TGFβ signaling leads to aberrant vascular ...
eLife1d
Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking
Reward-seeking involves the engagement and computation of multiple physiological and motivational parameters. The lateral hypothalamus (LH) is a necessary node in the circuits that control ...
eLife1d
First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France Department of Biology, University of New Brunswick, Fredericton, New ...
eLife2d
Homeostatic synaptic normalization optimizes learning in network models of neural population codes
The authors convincingly implemented the statistical inference of input likelihood in a simple neural circuit, demonstrating the relationship between synaptic homeostasis, neural representations, and ...