eLife16d
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretion
GDNF increased claudin-5 expression via the PI3K/AKT/FOXO1 and MAPK/ERK pathways. Meanwhile, GDNF promoted VE-cadherin expression by activating PI3K/AKT/ETS1 and MAPK/ERK/ETS1 signaling. The roles of ...
Science Friday29d
Mission Rehydrate: Water For A Thirsty Planet
Have you ever rinsed a bunch of grapes or a head of lettuce in a colander? Turn on the faucet, let the water pour over the fruit or veggies, and watch the water come out of the little holes in the ...
eLife7y
A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development
The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate border are well ...