Preventing siRNA effects from spreading to unspecified areas of the brain will require the use of viral expression of shRNA- or miRNA-based constructs. It is crucial to identify the location of β ...

In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished with an outer PEG shield (Figure 2A). The lipid bilayer contains a ...

She uses short interfering RNA (siRNA) screens and automated microscopy to identify genes involved in the shape, polarity and movement of human cells. “For me, I thought the hard part would be t ...

Here the authors developed and experimentally validated sChemNET, a deep learning framework to predict small molecules affecting microRNA function based on chemical structure and sequence data ...