Purpose: The mechanism of action and pharmacokinetics of sirolimus when used as part of a drug-eluting stent (DES) and the efficacy and cost of using DESs versus bare-metal stents are discussed.
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placement of stents within and across the GI lumens (using lumen apposing metal stents), confocal laser endomicroscopy (CLE), endoscopic mucosal resection (EMR), full thickness resection, ...
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[27] This will involve a bolus followed by an infusion prior to endoscopy then continuing either as an infusion or as a regular oral or intravenous dose depending upon the endoscopic findings.