eLife3d
A deep learning framework for automated and generalized synaptic event analysis
Here, we developed and evaluated miniML, a novel supervised deep learning approach for detecting spontaneous synaptic events. miniML provides a comprehensive and versatile framework for analyzing ...
eLife3d
Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells
This study provides important information about the formation of ribbon synapses in mouse cochlear hair cells, which facilitate the temporally-precise transmission of acoustic information to the ...
eLife3d
Presynaptic Rac1 in the hippocampus selectively regulates working memory
One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous ...
eLife3d
Novel Mechanism for Tubular Injury in Nephropathic Cystinosis
Understanding the unique susceptibility of the human kidney to pH dysfunction and injury in cystinosis is paramount to developing new therapies to preserve renal function. Renal proximal tubular ...
eLife3d
Sub-cone visual resolution by active, adaptive sampling in the human foveola
By using synchronous adaptive optics imaging and visual stimulation of the foveola, we find that the human visual system is capable of resolving spatial features smaller than a single photoreceptor ...
eLife3d
Pinging the Hidden Attentional Priority Map: Suppression Needs Attention
Attentional capture by an irrelevant salient distractor is attenuated when the distractor is presented more frequently in one location compared to other locations, suggesting that people learn to ...
eLife7d
Reconfigurations of cortical manifold structure during reward-based motor learning
Dimensionality reduction approaches on functional MRI data reveal that human reward-based motor learning emerges from dynamic changes in functional brain network interactions among sensorimotor, ...
eLife7d
Fast burst fraction transients convey information independent of the firing rate
Here we used a novel demultiplexing approach by considering a conjunctive burst code. We studied this code in vivo while animals learned to report direct electrical stimulation of the somatosensory ...
eLife2d
Viral Variants: How mutations affect function
A new study reveals how naturally occurring mutations affect the biophysical properties of nucleocapsid proteins in SARS-CoV-2.
eLife7d
Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio)
This important study by Franziska Auer and colleagues examines cerebellar Purkinje cells' role in controlling posture in larval zebrafish using the innovative chemogenetic tool TRPV1/capsaicin. This ...
eLife13d
Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity
Genetic engineering of murine myeloid cells reveals the challenges in ectopic expression of chemiric receptors and provides a novel framework to endow them with tumor-specific cytotoxic ability.
eLife6d
Visuo-motor updating in individuals with heightened autistic traits
Efference copy dysfunctions in heightened autistic traits impair the use of eye movement information for spatial representation and object localization.