To contrast our models of physiological hypertrophy, we employ several different models of pathological hypertrophy. These include acute or chronic adrenergic stimulation, high-fat (or Western) diets, ...

The presence of left ventricule hypertrophy (LVH ... simple and reproducible technique to assess LA myocardial function in patients with either physiological or pathological LVH. LA myocardial ...

from the blood of young mice possess the capacity to dramatically extend lifespan, rejuvenate whole-body physiology and reverse age-related degenerative changes in aged mice. The work is published ...

Prof McMullen is recognized internationally for research which defined the molecular distinction between physiological and pathological cardiac hypertrophy in mouse models of health and disease.