During an autologous SCT, you receive your own stem cells, which have been extracted and stored for use after high dose chemotherapy. SCTs are considered a secondary line of treatment in CLL.

They can then crowd out healthy cells and prevent them from ... more with their use as first-line therapy than in cases of refractory/relapse CLL. Both idelalisib and duvelisib are taken as ...

Therefore, we studied MEAC formation and the effects of MEAC binding on CLL cells. In cell line studies, both intrinsic (spontaneous or camptothecin-induced) and extrinsic (FasL- or anti-Fas ...

During a Case-Based Roundtable® event, Ryan W. Jacobs, MD, discussed a patient who received 2 prior lines of therapy for ...

Researchers also highlighted the significance of TTNT-D as a real-world measure of treatment efficacy, noting it provides ...

This second finding is in line with the results of another ... function properly in CLL patients. In CLL, these mitochondria become damaged, causing T cells to lose their power to attack cancer ...

A high tumor burden with large numbers of B cells results in more rapid elimination. Single agent: 55% overall response rate in untreated chronic lymphocytic leukemia (CLL). Fludarabine plus ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

This second finding is in line with the results of another ... 2024025525 Wael Gamal et al, Mitigating T-Cell Mitochondrial Dysfunction in CLL to Augment CAR T-Cell Therapy: Evaluation in an ...