How does DNA determine an organism’s characteristics? A process called translation decodes RNA created during transcription, and uses it to create proteins that perform specific cellular functions.

They then added the mRNAs one by one to a mix of ribosomes and aminoacyl-tRNAs with one amino acid radioactively labeled. For each, they determined whether the aminoacyl-tRNA was bound to the ...

The key structural features of tRNA include: The specificity of tRNA-amino acid interactions and the accuracy of codon-anticodon recognition ensure the faithful translation of the genetic code into ...

Wobble base pairing enables a single tRNA molecule to recognize multiple codons for the same amino acid, reducing the number of tRNA molecules required for translation. To ensure accurate translation, ...

Biologists have discovered that disruptions in transfer RNA function can lead to the development of cleft lip and cleft palate.

When they treated the cultures with synthetic tRNA that carried an easily traceable unconventional amino acid and recognized these rare codons, they found that the TCG triplet introduced the new ...

Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

the researchers identified 12 highly active tRNA synthetase/tRNA pairs in Escherichia coli that can add canonical and noncanonical amino acids. Then, Badran’s team used iterative rounds of genetic ...

We thought the ribosome was completely in destruction mode. So why was it bringing in a tRNA with an amino acid ready to be added on to the nascent chain?” Weissman says. “We initially just kind of ...

In this process, the tRNA molecules work as adapters that proofread the code and, upon a successful match, add the correct amino acids, i.e. the building blocks that make up proteins. For this ...