What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which ...

Revir Therapeutics has raised $30 million to advance the development of oral genetic therapies for ALS and other ...

Specific RNA Sequences Are Required for Regulation of Alternative Splicing If we want to understand the splice code, then we need to analyze the existing information about constitutive and ...

resulting in the removal of an entire exon during RNA splicing. Experimentation involving the introduction of these Alu elements into mice revealed a loss of tails, mirroring the evolutionary ...

A pioneering study has provided new insights into immune system aging by examining alternative splicing in T cells.

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to ...

Working at the interface of RNA splicing and breast cancer biology, our current focus is on regulation of breast cancer metastasis driven by alternative splicing. We use molecular biology, genomics, ...

– CONNECT1-EDO51 clinical trial data from low-dose cohort were reported in July. PGN-EDO51 at 5 mg/kg was well tolerated, achieved mean exon skipping levels of 2.15%, mean muscle-adjusted dystrophin ...

BACKGROUND: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. RNA-binding proteins are identified as regulators of cardiac disease; DDX5 (dead-box helicase 5) is a master ...

Ongoing research aims to enhance treatment through innovative therapies and emerging targets like RNA splicing dysregulation and metabolic vulnerabilities in chronic lymphocytic leukaemia cells. These ...