For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.

However, production of the mRNA used in vaccines is hindered by its production, which involves both chemical synthesis and a slower enzyme-mediated process. A team of researchers has successfully ...

mRNA vaccines have gained widespread attention for their crucial role in fighting the COVID-19 pandemic. Yet, even before the ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

Mugridge JS, Tibble RW, Ziemniak M, Jemielity J, Gross JD. Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature Communications (2018 ...

In 2021, with the COVID-19 pandemic in full swing, BioNTech (NASDAQ:BNTX) and Moderna (NASDAQ:MRNA) were the darlings of the pharma and biotech worlds. The two mRNA therapy developers created ...

Researchers discover that COVID-19 mRNA vaccines do not generate long-lasting plasma cells in the bone marrow, shedding light on why antibody immunity wanes quickly, and highlighting the urgent ...

GSK has filed a pair of lawsuits against Moderna, claiming infringement of patents covering mRNA vaccines for COVID-19 and respiratory syncytial virus (RSV). According to court documents ...

It's been a sad week for Moderna, Inc. ( NASDAQ:MRNA ), who've watched their investment drop 14% to US$46.83 in the... On Thursday, Moderna Inc. (NASDAQ:MRNA) reported third-quarter revenue of $1. ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

However, the speed of vaccine production is limited because the mRNA used in it is partly chemically synthesized and partly synthesized using enzymes, a relatively slow process. A team of ...

The phosphorylation reagent with a nitrobenzyl hydrophobic tag allows production of high purity fully chemically synthesized mRNA and transcriptionally synthesized cyclic mRNA. In an era where ...