The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.

Researchers have regressed human stem cells to an embryonic state using just a single transcription factor, as opposed to the four factors previously needed to induce pluripotency in human cells, ...

Transcription factors activate genes through the phase separation capacity of their activation domains. Cell 2018, 175: 1842-1855. Taatjes, DJ. Transcription factor–Mediator interfaces: multiple and ...

Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential ... exhibited expanded pluripotency, expressing ...