Aim: Little information is available regarding the influence of CYP3A5 genetic polymorphisms on tacrolimus dose requirement in pediatric liver transplantation. Patients & methods: We performed a ...

Hispanic and black patients); monitor blood glucose. Hepatic or renal impairment; monitor and consider dose reduction. Obtain tacrolimus whole blood concentrations, serum creatinine, serum ...

Renal impairment, moderate or severe hepatic impairment: monitor and reduce dose if indicated. Obtain tacrolimus whole blood concentrations (see full labeling), serum creatinine, and serum ...

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Pharmacogenomics. 2013;14(9):1017-25. CYP3A5 expressors needed more tacrolimus dose modifications to reach stable tacrolimus therapeutic trough concentrations compared with CYP3A5 nonexpressors ...