Lower affinity antibodies against the transferring receptor, anti-TfR^D and anti-TfR/BACE1 (anti-TfR/BAC1) can cross the blood-brain barrier to reach neuronal targets in the brain as indicated by ...

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Transferrin receptor (TfR)-mediated transcytosis is a receptor-mediated mechanism for drug delivery to the brain or other tissues, where, after the antibody binds to transferrin, the therapeutic agent ...

Caption Anti-TfR/BACE1 – red is the neurons in the brain and green is the antibody stain showing that the engineered antibody can get into the brain and bind to neurons. This video relates to a ...