Eukaryotic RNA polymerases use a number of essential cofactors (collectively called general transcription factors), and one of these, TFIID, recognizes the TATA box and ensures that the correct ...
The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator, and RNA polymerase II (pol II). As a central integrator of both general and TF-specific regulatory signals, Mediator plays a ...
(August 2021) News & Views article published in NSMB that summarizes the remarkable recent cryoEM structures of the human PIC, including TFIID and Mediator. (June 2021) Publication in JMB that further ...