Another cofactor, TFIIB, recognizes a different common consensus sequence, G/C G/C G/C G C C C, approximately 38 to 32 bases upstream (Figure 4). Enhancer sequences do what their name suggests ...
The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator, and RNA polymerase II (pol II). As a central integrator of both general and TF-specific regulatory signals, Mediator plays a ...
To provide the structural basis for the polarity of transcription, we determined the 2.65-Å resolution crystal structure of a human ternary TBP-TFIIB-DNA complex, consisting of the core domains of ...
The general transcription factor TFIIB plays a central role in the assembly of the transcription complex at the gene promoter. TFIIB is also a target of transcriptional activator proteins, which act ...
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