between two inbred mouse strains (C3H and DBA/2). Traditional backcross breeding strategies were used to generate reciprocal congenic lines in which the DBA/2 allele of Chrna5 or Chrna7 has been ...

There is general appreciation that 'genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to ...

Previous research has shown that aberrant sphingolipid metabolism, which is evidenced by elevated levels of circulating ceramide, is associated with poor prognosis in patients with prostate cancer (PC ...

Figure 4: Dopamine D 2-receptor-deficient mice show reduced sensitivity to ethanol-induced ataxia. Incipient congenic mice (N5) on a C57BL/6J background were used in all experiments; these mice ...