Changes in brain connectivity before and after puberty may explain why some children with a rare genetic disorder have a ...

Synaptic dysfunction is a core component of the pathophysiology of schizophrenia. However, the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully ...

First author Hamilton Oh, now at Icahn School of Medicine at Mt. Sinai, New York, and colleagues identified these potential markers during a proteomics analysis of CSF from 3,397 participants in six ...

Furthermore, synaptic dysfunction is being increasingly recognized as a critical underlying etiology of many neurological disorders, such as epilepsy and autism. Thus, the long-term research goal of ...

A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

Dr. Südhof added, “Synaptic dysfunction and loss are known precursors to both neuropsychological and neurodegenerative disorders. Boost’s proprietary platform allows for the discovery and ...

Small intermediates — soluble oligomers — in the aggregation process can confer synaptic dysfunction, whereas large, insoluble deposits might function as reservoirs of the bioactive oligomers.

Jennifer Morgan, senior scientist at the Marine Biological Laboratory, Woods Hole, studies how the synapse malfunctions in devastating diseases such as Parkinson’s and Lewy body dementia. Now, her lab ...