New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
The central dogma of biology defines the flow of genetic information: It describes how proteins are made from mRNA templates, ...
Nature12y
RNA Splicing: Introns, Exons and Spliceosome
What's the difference between mRNA and pre-mRNA ... sequences at their splice sites, eukaryotic genes with long introns also contain exonic splicing enhancers (ESEs). These sequences, which ...
Nature1y
Regulation of mRNA Splicing by Signal Transduction
Expansion of the eukaryotic proteome by alternative splicing ... Cell signalling and the control of pre-mRNA splicing. Nature Reviews Molecular Cell Biology 5, 727–738 (2004) doi:10.1038 ...
Slow editing of protein blueprints leads to cell death
An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this ...
eLife13d
An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing
This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...
“Astonishing” – Scientists Unveil First Blueprint of the Most Complex Molecular Machine in Human Biology
Researchers unveil the inner mechanisms of the most intricate and complex molecular machine in human biology. Scientists at the Centre (CRG) in Barcelona have developed the first comprehensive ...
The Scientist22d
Gene Proximity to Nuclear Speckles Drives Efficient mRNA Splicing
One such nuclear body, the speckle, contains spliceosomes that are known to be involved in mRNA splicing. Disruption of speckles leads to a range of diseases and developmental disorders, yet how ...