Kinesins propel across a larger cellular structure—the mitotic spindle—made of long, thread-like filaments called microtubules. Kinesin-5 helps these filaments slide against each other, building a ...

We are working to understanding how the mitotic spindle organizes and moves chromosomes. Recent projects have focused on the contributions of kinesin-8 motor proteins to chromosome movements, and ...

The identification of proteins that are important for microtubule nucleation, regulation of microtubule dynamics and spindle assembly ... the plus-end-directed kinesin Eg5, or by a specific ...

The key features of the Vincerx platform are: • a large toolbox of effector chemistries and potent payload classes, including kinesin spindle protein (KSP) inhibitors, with a novel mode of ...