Summary: Heart failure is a clinical syndrome ... resulting in the activation of the renin–angiotensin–aldosterone system, which compensates for the hypoperfusion. However, this contributes ...

Chronic heart failure (CHF) is associated with frequent ... and aliskiren (a direct renin inhibitor), show promising outcomes in the treatment of HTN in HF patients.

Heart failure with preserved ejection fraction ... a sodium–glucose cotransporter 2 inhibitor (SGLT2-i), renin–angiotensin–system inhibitor (RAS-i), or mineralocorticoid receptor antagonist ...

Chronic heart failure occurs when either the left ... [Hurst’s The Heart Section 11:13a,14a-b,15a] Although the renin-angiotensin-aldosterone system is activated in HFpEF, it is not as prominent ...

and other members of the renin angiotensin system in the development of hypertension, metabolic syndrome, and heart failure. Research in the Exercise Physiology Laboratory focuses on how the human ...

Scientists have discovered that long-term use of common medications for high blood pressure and heart failure could contribute to kidney damage. While these drugs, including ACE inhibitors, are ...

The project aims to elucidate the regulatory role of the upstream proteolytic network in renin-angiotensin-aldosterone system ...

The guideline describes persons with stage A disease as being “at risk for HF;” they lack HF symptoms, structural and/or functional heart ... (MRAs), and renin-angiotensin system inhibitors ...

Chronic heart failure is a syndrome ... and activation of the renin-angiotensin-aldosterone system (RAAS). Medical therapy is aimed at reducing the activity of these two systems.