In the 1930s, Muller was surprised to note that telomeres were strangely resistant to mutagenic X-rays. Why are the unique properties of these chromosomal "end caps" so important? Thus ...

W. Szostak and Carol W. Greider — was awarded the Nobel Prize in Physiology or Medicine for her help in discovering "how chromosomes are protected by telomeres." Telomeres protect our DNA ...

Cells use homologous recombination to stitch double-stranded breaks (DSB) back together and the enzyme telomerase to cap exposed ends of a DNA strand with a repetitive DNA sequence called a telomere.

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...

Researchers at Washington State University (WSU) have developed genetically engineered mice with human-like telomeres, offering a new model for studying aging and disease. The findings, published in ...

Then they exposed the cells to a mixture of antigens composed of pieces of various viruses, to ensure that the APC and T cells joined up to replicate a real immune response. Finally, they analyzed the ...

People with shorter protective caps at the end of their chromosomes (called telomeres) may be more likely to develop age-related brain diseases such as stroke, dementia and late-life depression ...

“This is the first mouse model with truly humanized telomeres because telomerase isn’t expressed in adult tissues in this model,” said Jiyue Zhu, PhD, professor, college of pharmacy and phar ...

"Telomeres are the nucleotide endcaps of our ... “If you want to see a real difference in slowing your biological aging, it appears that a little exercise won’t cut it,” he said.

Figure 1: Telomere shortening has contrasting effects on the survival of Apc Min mice. Figure 2: Contrasting effects of telomere shortening on tumor formation in Apc Min mice. Figure 5 ...

About Telomere Biology Disorders and EXG-34217 Telomere biology disorders (TBDs) are a group of rare genetic conditions characterized by very short telomeres, the protective end caps of ...