The sequence of the RNA component, the aptamer, can be fused to the 3' end of the gene of interest, similar to the addition of a FLAG tag or GFP to a protein of interest. When transcribed, the final ...

Using unnatural base pairs, researchers have site-specifically biotinylated RNA, allowing them to immobilize an aptamer on a chip and detect its interaction with a target protein. Experiments with ...

With the addition of a ligand-sensing aptamer sequence, a self-replicating RNA enzyme system enables general molecular detection, analogous to that of quantitative PCR. With the ultimate goal of ...

qPCR analysis shows the level of p53 mRNA in H1299-R175H cells 24 hours after transfection with dp53m ... They reported an RNA aptamer-based PROTAC degrader capable of targeting and degrading ...

Researchers use modified RNA transfection to correct genetic dysfunction in heart stem cells derived from Barth syndrome patients. The series of images show how inserting modified RNA into ...

For the development of two bright multi-colour fluorogenic aptamer tags, and for demystifying the fluorescence activation mechanism, enabling efficient imaging of diverse RNAs in living cells.