Most mutations that decreased antibiotic susceptibility were related to specific metabolic pathways. A MIC-increase to ...

Recent research has focused on understanding the roles of different enzymes involved in nucleotide metabolism, particularly in the context of purine and pyrimidine nucleotide biosynthesis and ...

GTP is another purine nucleotide that plays a crucial role in cellular signaling ... GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism ... reflect a decrease in nucleotide production within ...

2 Gerta Hoxhaj, a cancer metabolism ... are a potential source of purines for the salvage pathway, Hoxhaj’s team wondered whether supplementing mice with nucleotides could impact tumor growth. They ...