When a brain injury occurs, microglia—phagocytic cells that reside in the central nervous system—flock to the site to clear injured neurons and allow tissue regeneration. Monitoring the process in ...

New research reveals that the immune checkpoint molecule Tim-3 plays a critical role in how microglia, the brain’s immune cells, respond to Alzheimer’s disease.

The researchers found that the number of microglia in a phagocytic state – indicating they were actively cleaning up debris ...

Microglia are special cells in the human brain. Like a diligent ranger overseeing a forest and dealing with infestations and wildfires, microglia scan the brain environment for germs and initiate ...

Genome-wide association studies have identified >20 loci with high Alzheimer’s Disease (AD) susceptibility, many of which overlap with genes highly expressed in microglia. These findings highlighted ...