appendages (e.g., pili and flagella), or polysaccharide capsules. After binding the bacterial receptor, the phage undergoes a conformational change through complex mechanisms that ultimately open a ...

The binding sequences identified through phage display could be isolated, reinserted into an existing human IgG backbone, and expressed in bacterial or mammalian cells. “It completely opened the door ...

An isolated repressor is shown here to bind specifically and with high affinity to DNA, strongly suggesting that, in vivo, repressors block the transcription from DNA to RNA by binding directly to ...

Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials ... these infections begin with virion binding to specific cell-surface receptors ...

For instance, they envision it being used to identify the best-binding phages for specific bacterial strains, including perhaps from patient samples. The ability to achieve improved phage ...

The phage-displayed peptide is linked to an amplifiable readout, encoded on the viral genome. This allows a library to be searched with binding molecules such as antibodies, receptors and enzymes, ...