However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...

Under normal, unstressed conditions, a key negative regulator of p53 is MDM2, which binds to the transactivation domain of p53 and ubiquitylates the protein, targeting it for degradation.

The levels of p53 and Mdm2 are balanced through autoregulatory feedback loops — the RING-finger protein Mdm2 binds to p53 at its transactivation domain and thereby inhibits its transactivation ...

My colleagues and I are studying two other closely related proteins that regulate p53 by marking it for destruction when it's ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

enhancing MDM2 transcription independent of p53. Researchers from the University of Houston and Baylor College of Medicine presented preclinical data for MA-242, a dual inhibitor of MDM2 and NFAT1, ...

Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this and didn’t know what to make of it,” Levine said. “Because it wasn’t isolated like an ...

It also develops APG-2575, an oral administered Bcl-2 selective inhibitor for hematologic malignancies and solid tumors; APG-115, an oral small molecule inhibitor of the MDM2-p53 protein-protein ...