The discovery of the Bcl-2 protein family, as well as p53 and its involvement in regulating apoptosis, and the CD95 (also known as FAS or APO1) pathway, led to an understanding of the molecular ...

Under normal, unstressed conditions, a key negative regulator of p53 is MDM2, which binds to the ... SOCS2 = suppressor of cytokine signalling 2; SOD2 = superoxide dismutase; [Mn] = mitochondrial ...

More than 140,000 articles have been published on molecules that mediate the intrinsic and extrinsic apoptotic cascades, such as BCL-2, TNF, NF-κB and p53. This interest in part stems from the ...

A new combination therapy involving sonrotoclax and dexamethasone demonstrated safety, antitumor activity, and early ...

highly potent Bcl-2 and dual Bcl-2/Bcl-xL inhibitors, as well as candidates aimed at IAP and MDM2-p53 pathways, and ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

though we have also become interested in the ability of p53 to restrict lineage plasticity (2). Using a murine model of pancreatic ductal adenocarcinoma (PDAC) in which endogenous p53 can be switched ...

A new research paper titled "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells" has been published in Oncotarget.

There is evidence that lower doses may be equally effective, especially in patients with less severe edema. [10] If beneficial, neurological improvement can be expected within 48 h with this ...

If you want to know what to expect from the Nintendo Switch 2 then we're here to help. We've rounded-up all the latest rumours on Nintendo's next console, including leaks on the Switch 2 release ...

BCL Industries Ltd share price was up by 2.32% from the previous closing price of ₹56.53. Who are peers of BCL Industries Ltd? The peers of BCL Industries Ltd are 3M India Ltd, Swan Energy Ltd ...