A new study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved ...

One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.

A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The ...

Effect of p38 MAPK inhibitor(s) on the survival of cultured PGCs Oct4 ... chemical compounds as potent and selective inhibitors with JAK inhibitor I (JAKi) (Janus kinase inhibitor, Millipore, 420099), ...

Shanghai Meiyue Biotech Development Co. Ltd. has discovered MAPK p38 inhibitors reported to be useful for the treatment of arthritis, psoriasis, systemic lupus erythematosus, diabetes, cancer, ...

Cell 7, 421–432; 2001), Cavalli and co-workers now show that a well-characterized signalling pathway that involves the MAP kinase family member p38 can regulate the rate of endocytosis by ...

the authors have also determined an essential role for TNFR Wgn — but not Grnd — in the activation of p38 kinase. "In healthy cells, this p38 will be responsible for setting in motion the ...

PF-07265803 – a p38 mitogen-activated protein kinase (MAPK) antagonist also known as emprumapimod – was being tested as a treatment for symptomatic dilated cardiomyopathy (DCM) due to a ...

The company is also developing Navicixizumab (OMP-305B83), which has completed Phase 1b clinical trials for the treatment of the late line ovarian cancer; Acumapimod (BCT-197), a p38 MAP kinase ...

the authors have also determined an essential role for TNFR Wgn — but not Grnd — in the activation of p38 kinase. “In healthy cells, this p38 will be responsible for setting in motion the ...