Nucleoside analogs are transformative in cancer and antiviral therapies, offering new avenues for treatment despite ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Lactic acidosis is a rare but often fatal complication reported in some human immunodeficiency virus (HIV)-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors.

In addition, some nucleoside analogue reverse transcriptase inhibitors (most notably zalcitabine and stavudine and, to a lesser extent, didanosine) represent an important contributor to peripheral ...

Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...