Several factors contraindicate PICC placement: lack of peripheral access, venous thrombosis, and end-stage renal disease. In addition, PICCs should not be used for frequent intermittent access or ...

Vein irritation can occur during PICC insertion or when the vessel is too small to accommodate the diameter of the PICC. A PICC that is too large will abrade the intima of the vein into which it ...