Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical ...
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Targeted centrosome inheritance during CD8⁺ T cell division plays role in memory precursor cell generation: StudyA recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8 + T cell division for the generation of memory precursor cells.
They discovered that DB1's antitumor efficacy is closely linked to tissue-resident memory (TRM) CD8 + T cells within the tumor, which are reinvigorated and expanded following DB1 therapy.
These effects require prior TCR engagement. This restriction to antigen-stimulated T cells and a more pronounced expansion of memory CD8+ T cells differentiates TNFRSF25 from other T cell ...
Ten years of substantial work by Nathalie Labrecque's team at the Montreal Clinical Research Institute (IRCM) and the ...
Vaccine-induced T cells transitioned from proliferative to effector states and stabilized as tissue-resident memory-like (TRM-like) cells, retaining cytotoxic functions for years. Persistent CD8 ...
Once acquired infection persists for life requiring continuous life long cellular immunity (CD8 memory T cell and IFNγ dependent) for host survival. Development of this response relies on both ...
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