The use of the heterogeneous and ill-defined 3D cell culture platform Matrigel has facilitated organoid culture with impressive versatility but is not without limitations. In particular, culture in ...

1 - Hartman CD, et al. Extracellular matrix type modulates cell migration on mechanical gradients. Experimental Cell Research, 359(2):361-366, 2017. 2 - Bryant DM, et al. A molecular switch for the ...

2 Organoid culture protocols are continuously improving ... Scientists can embed the differentiated embryoid bodies in Matrigel droplets and either cryopreserve or continuously culture them for ...

Researchers from the Organoid group have developed a novel ... Currently, researchers use basement membrane extracts like Matrigel and BME for this purpose. While effective, these extracts are ...

While not exact replicas of human organs, they offer significant insights. Scientists now present a new organoid model that reveals details of the developing nervous system's response to viral ...

“This groundbreaking model advances the tissue organoid field by recognizing and correcting for the absence of the necessary supporting matrix to a 3D structure, in this case, the meninges ...

This groundbreaking model advances the tissue organoid field by recognizing and correcting for the absence of the necessary supporting matrix to a 3D structure, in this case, the meninges." ...

By promoting liver progenitor cell expansion through a specific signaling pathway, this method offers a promising route to improve organoid models and regenerative medicine. Organoids are small ...