A major cause of inflammatory bowel disease (IBD) has been discovered ... is highly implicated in IBD are white blood cells called macrophages. These flood the linings of the intestines where ...
Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the ...
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Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers"This study shows that FXR plays a crucial role in regulating how macrophages behave in the gut," says Fu. "This could be really important for developing new treatments for IBD and colitis ...
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Researchers identify key driver of fibrosis in Crohn's diseaseCrohn's disease ... to patch up wounds in the body. When macrophages are actively fighting infections or responding to inflammation (as is the case with IBD), they activate a protein called ...
PKM2 acts as a critical nonmetabolic regulator of macrophage pyroptosis by increasing NLRP3 expression promoting NLRP3 inflammasome activation via nuclear translocation and enhancing STAT3 ...
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