There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, ...

More information: Alexandra Blackman et al, MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine ...

Instead, I have chosen to focus on two of perhaps the most surprising and influential findings that involve the oncogene MYC and the tumour suppressor p53, which have an interlinked history in our ...

Researchers have elucidated the role of the p53 gene in ulcerative colitis. The study suggests a potential new drug target to stop disease progression to cancer. Researchers in the lab of Michael ...

The aim of our group is to understand the function and regulation of the transcription factors p53 and c-MYC, as well as the processes and genes which they regulate. c-MYC and p53 are genes which are ...

Blocking CKIα, CDK7, and CDK9 augments and synergistically stabilizes p53 and down regulates Myc and MCL1 promoting the rapid killing of leukemia cells as well as leukemic stem cells. Pre ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study ...