While it's known that major histocompatibility complex class I (MHC-I) plays a central role in orchestrating immune responses to cancer, less is known about the reactivity of peptides displayed by ...

Recently developed major histocompatibility complex (MHC) multimer technologies allow visualization and isolation of antigen-specific T cells. However, functional analysis and in vivo transfer of ...

The vaccine derived-peptide binds MHC class I molecules (5). Peptide antigen/MHC I complexes are presented on the cell surface (6), binding cytotoxic CD 8+ lymphocytes, and inducing a cell ...

The field of immunology has long recognized the pivotal role of T lymphocytes in the adaptive immune system, particularly in pathogen defense, tumor ...