Kumamoto University researchers identified ATP-citrate lyase (ACLY) as a key enzyme in driving chronic inflammation in aging ...

A team at Kumamoto University has made a discovery that could help promote healthy aging. As the world's population ages, ...

A team has made a groundbreaking discovery in the field of aging and inflammation. Japan's aging population is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather ...

In a series of in vivo and in vitro studies, the investigators established that astrocyte immune memory is driven by an epigenetic program driven by p300 and ATP-citrate lyase (ACLY)—enzymes that help ...

This funding, provided through the NIH’s Somatic Cell Genome Editing Program, will support gene-editing research aimed at ...

A team at Kumamoto University has made a groundbreaking discovery in the field of aging and inflammation. Japan's aging population is growing at an unprecedented rate, making it crucial to extend ...

Organomercurial lyase (MerB) catalyzes the difficult cleavage of C-Hg bonds to hydrocarbon and mercuric dithiol products. Model compounds providing two or three thiolate ligands activate ...

BACKGROUND: Aortic valve disease (AVD) is associated with high mortality and morbidity. To date, there is no pharmacological ...

Das Enzym Pyruvat-Formiat-Lyase (PFL) katalysiert die Reaktion von Pyruvat zu Acetyl-CoA und Formiat (Anion der Ameisensäure). Es ist Teil des anaeroben Energiestoffwechsels einiger Bakterien wie z.B.

TNF inhibitors show clinical benefits for Behçet’s disease (BD), but the underlying molecular insights are still unclear. Here the authors use both patient samples and mouse genetic models to ...

The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating SASP. This discovery was made using advanced ...