Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra-individual variation in ...

[23] Electrolyte imbalance, particularly hypokalemia, is the most common adverse effect of loop diuretics. Through this mechanism, diuretics may increase mortality (especially arrhythmic deaths).

Bumetanide is a loop diuretic that is currently available as an oral and injectable therapy. If approved, the nasal spray formulation would provide an additional option for self-administration in an ...