Luckily, the same technological advances that enabled the T2T human genome assembly are now breaking down the technological barriers that limited earlier pangenome projects. Unlike a linear reference ...

Cornell University researchers have discovered a new mechanism these genes use to survive and propagate in bacteria with linear DNA, with applications in biotechnology and drug development.

Understanding the order of these nucleotides in linear DNA molecules has been an active pursuit since the discovery of DNA’s double-helical structure (Watson et al. 1953). As such, DNA ...

2004). Also, whereas bacterial chromosomes are circular, eukaryotic chromosomes are linear. During circular DNA replication, the excised primer is readily replaced by nucleotides, leaving no gap ...

To my surprise, this linear form of SV40 DNA was infectious. But when I recovered the SV40 DNA and looked at it, it was no longer linear. It had become super-coiled circular DNA again. And the EcoRI ...

While most bacterial DNA is in the form of plasmids, there are some that have linear DNA that contain telomeres. Though the presence of telomeres at the ends of the linear DNA is similar to ...