“Lipid nanoparticles really address the question of delivery.” Wong was particularly excited that the lung SORT LNP reached the basal cells in the lung epithelium. “If you target these stem cells, ...

“We’ve combined the SORT LNP delivery toolbox with expertise in mRNA design, optimization, purification, and production. The mRNA has been optimized to maximize protein production within ...

With regards to drug targeting, LNP delivery into specific cell and tissue ... AAV6, for example, is known to target skeletal muscle, AAV8 is a workhorse for liver-based applications, and AAV9 ...

Unfortunately, even when LNPs reach their target cells, the nanoparticles ... collaborators demonstrate that BEND lipids improve LNP delivery of mRNA and gene-editing tools, in some cases by ...

The LNP nanoparticle is one of the most advanced mRNA delivery systems ... trials that require accurate and precise detection of target analytes or pathogens. Two critical parameters need to ...

BASEL, Switzerland and VANCOUVER, British Columbia and WARMINSTER, Pa., March 03, 2025 (GLOBE NEWSWIRE) -- Genevant Sciences, a leading nucleic ...

By packaging the nucleic acid polymer in well-defined nanoparticles, LNPs protect the nucleic acid payload in vivo and facilitate intracellular delivery following uptake into target cells by ...

Orna, which was founded around circular RNA technology, gained the LNP technology for the delivery of RNA-based ... to use the STAC-BBB capsid for one target, with the right to add up to four ...