The team at the CRG altered the expression of 305 spliceosome-related genes in human cancer cells one by one, observing the effects on splicing across the entire genome. Their work revealed that ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain ...

A breakthrough tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to create precise genetic mutations ...

Researchers unveil the inner mechanisms of the most intricate and complex molecular machine in human biology. Scientists at the Centre (CRG) in Barcelona have developed the first comprehensive ...

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...

For the first time, researchers were able to detect altered gene 'splicing' (a process that can make cancer cells resistant to PARPi therapy) in the blood. The findings can be immediately applied ...

Harvard researchers pioneered a method called HACE for targeted gene mutations, advancing genetic research potential.

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...