The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

As CSCs are endowed with the ability to self-renew, a wave of preclinical investigations has tried to assess the therapeutic relevance of inhibiting developmental pathways (Hedgehog, Notch ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...

Together, these data suggest altered hedgehog ... in MDA-MB-231 cells mediates osteolytic behavior of these cells via induction of parathyroid hormone-related protein. Other than these studies, the ...

17, 2024 — Research provides evidence that a drug used to slow the progression of the disease ALS shows promise in suppressing the self-renewing cancerous stem ... pathway that is used by cancer ...

Prostate cancer is the second most common cancer in men worldwide. Despite medical advances in recent years, this type of ...

Neural stem cells are the source of the ... "Disruptions in the SUMOylation process and Hippo pathway are linked to various illnesses in humans, including cancer and neurodegenerative diseases ...

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic ...

2024 — Researchers built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer. These findings ...

When you have an allogeneic stem cell transplant, stem cells are harvested (collected) from a donor. For either type of transplant, you first get high-dose chemotherapy to kill cancer cells. Two days ...

Half of donors back out when informed they are a match. Here's one writer's personal account of donating—and why she'd do it ...