Tsai and colleagues now show that in neurons HDAC2 is responsible. The authors generated mice that overexpressed either HDAC1 or HDAC2 specifically in neurons. In Pavlovian fear conditioning tests ...

GlobalData’s report assesses the drugs in the Histone Deacetylase 2 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

HDAC1 and HDAC2 are nearly identical and are generally found together in repressive complexes such as the Sin3, NuRD, CoREST and PRC2 complexes 21. HDAC3 is found in distinct complexes such as the ...

The study, called TOPARP-A, found that up to 30% of men had tumours with DNA repair defects including mutations in BRCA2, BRCA1, PALB2, ATM, or HDAC2, detected by genomic testing – and these patients’ ...