After they are incorporated into DNA, the drugs block DNMT enzymes from acting, which inhibits DNA methylation. Drugs aimed at histone modifications are called histone deacetylase (HDAC ...

Antoinette S. Perry; R. William G. Watson; Mark Lawler; Donal Hollywood The final two classes of HDAC inhibitors consist of the electrophilic ketone, trifluoromethylketone, and the miscellaneous ...

Concerns about HA-based HDAC inhibitors such as genotoxicity, rapid clearance and extensive metabolite formation, led CKD’s research team to identify a series of NHA molecules that selectively ...