Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals from membrane receptors to nuclei. They used nuclear magnetic ...

Researchers at Tokyo Metropolitan University have uncovered new details about how the proteins GRB2 and SOS1 transmit signals from membrane receptors to cell nuclei. By using nuclear magnetic ...

Signal transduction by GRB2 and SOS1. When some substances bind to a membrane receptor, a reaction occurs between the receptor and GRB2, which then goes on to bind and activate SOS1.

1). Although attention has historically focused on Grb2-mediated recruitment to receptor tyrosine kinases as a means of localizing SOS to the plasma membrane, recent work has revealed increasing ...

The IR bound IRS-1 is then itself tyrosine phosphorylated, creating a binding site for the SH2 domain of the adapter protein Grb2. The two SH3 domains of Grb2 bind proline rich motifs in the C ...

A study conducted at the Center for Research on Redox Processes in Biomedicine (Redoxoma) helps understand how high blood sugar (hyperglycemia), one of the manifestations of diabetes, can cause ...

Tetsu Narumi,Kazuhiko Fukui, Takaho Terada, Makoto Taiji, Mikako Shirouzu, Shigeyuki Yokoyama, and Akihiko Konagaya: "Molecular Dynamics, Free Energy, and SPR Analyses of the Interactions between the ...