G protein-coupled receptors (GPCRs) are the largest group of membrane proteins. GPCRs' primary function is to convert a wide range of extracellular stimuli, including biogenic amines, peptides, ...

With approximately one third of all current FDA-approved drugs targeting GPCRs, Verily/Sosei Heptares ... consisting of proprietary immune profiling lab workflow, growing multi-omic database ...

in a protein such as a GPCR, each amino acid might play a different role in how the protein responds to an external signal. Researchers at St. Jude, in collaboration with scientists from Stanford ...

I loved being in the lab. Challenges fuelled me. The project was too risky to hand over to students. Small improvements gave ...

To deal with multipass transmembrane proteins, the Zhu Lab recently invented Virion Display (VirD) technology that provides membrane environment to maintain correct conformation and function of ...

The long-lasting CAR T cells generated by the therapy could be restimulated by readministering CAR-E, the authors said. This ...

We utilize a variety of platforms, techniques and collaborations in order to progress GPCR discovery projects towards clinical development. Research in this laboratory covers a range of disciplines ...

In fact, 30-50% of all FDA-approved drugs target GPCRs. A major focus in Trivedi’s laboratory research is to identify GPCR targets and drugs in treatment of breast cancer and other types of cancer.

GPCRs are the largest receptor class ... Molecular dynamics simulations and dPaCS-MD/MSM calculation, performed at Dr. Kitao lab, indicate that G s forms more interactions with A 2A R and has stronger ...

State Key Laboratory of Experimental Hematology, Institute of Hematology, Zhejiang University and Zhejiang Provincial Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China.

The research team from the Laboratory of GPCR Biology, IIT Kanpur included Prof Arun K Shukla, Department of Biological Sciences and Bioengineering and Principal Investigator GPCR Lab; Ramanuj ...

To deal with multipass transmembrane proteins, the Zhu Lab recently invented Virion Display (VirD) technology that provides membrane environment to maintain correct conformation and function of ...