"If FOXA1 binds the synthetic sequences we introduced into a cell, we can capture that bit of DNA and determine its sequence to learn how the variants impact binding," Bai said.

A new UK biotech, Azeria Therapeutics has started on a mission to develop breakthrough treatments for drug-resistant breast and prostate cancer, based around a new target known as FOXA1.

“This is the machinery around the genes we know are involved in prostate cancer development, including androgen receptor, ERG and FOXA1. They all use this machinery to regulate oncogenic expressio ...

Study: NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis. Image Credit: Kateryna Kon/Shutterstock.com In a recent study published in Nature Genetics ...

"This is the machinery around the genes we know are involved in prostate cancer development, including androgen receptors, ERG and FOXA1. They all use this machinery to regulate oncogenic expression.

“This is the machinery around the genes we know are involved in prostate cancer development, including androgen receptor, ERG and FOXA1. They all use this machinery to regulate oncogenic expression.

NSD-2-dependent AR locations contain the chimeric forkhead box protein A1 (FOXA1): androgen receptor motif, which comprises tumor-specific androgen receptor enhancer circuits. NSD-2 functions as a ...