These inhibitors are typically small molecules designed by considering the structure of the active site or the substrate specificity of the enzyme. A common problem with small inhibitors ...

Inhibitors can be used to stop an enzyme from binding to its substrate. As a result, inhibitors can directly control the progress of a metabolic pathway.

11) and our understanding of ACE made a compelling argument for a new attempt at designing small molecular weight inhibitors. We had at our disposal not only an enzyme assay but also a highly ...

Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous substrate arachidonic acid, the mechanism of ...

An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, ...

Inhibition was determined by the depression ... to the hyperlipemia itself simply because of excess of substrate and subsequent enzyme exhaustion, or because of abnormal lipoproteins, resistant ...

This illustration depicts the process of enzyme catalysis. The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate ...