Antimicrobial resistance has recently increased due to emerging carbapenem-resistant Klebsiella pneumoniae and extended-spectrum β-lactamase (ESBL)-producing strains of K. pneumoniae, especially ...

and it allowed for the faster consolidation of empiric antibiotics. This protocol also restricted ertapenem use to approval by an infectious diseases physician for documented ESBL infections.

Three of these six pathogens are antibiotic-resistant Gram-negative bacteria. Recently, antibacterial drugs against ESBL-producing Gram-negative bacteria accounted for ∼15% (2 out of 13 ...

Although additional testing is necessary to prove the compound is safe and effective for use as future antibiotic ... as extended-spectrum beta-lactamase (ESBL) producing E.